Biostatistics 666: Analysis of Low Pass Sequence Data

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Discussion of the challenges involved in sequencing thousands of individual genomes. Introduction to the analysis of low pass sequence data.

Lecture Notes

Slides in PDF Format

Recommended Reading

  • The 1000 Genomes Project (2010) A map of human genome variation from population-scale sequencing. Nature 467:1061-73
  • Li Y, Willer CJ, Ding J, Scheet P and Abecasis GR (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34:816-834
  • Le SQ and Durbin R (2010) SNP detection and genotyping from low-coverage sequencing data on multiple diploid samples. Genome Research (in press)