Biostatistics 666: Modeling Recombination and Migration in the Coalescent

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Objective

This is the last class in our series introducing the coalescent. It introduces recombination and migration and discusses how the coalescent can be used to learn about a population genetic parameters.

Slides

Slides in PDF format

Recommended Reading

Richard R. Hudson (1990) Gene genealogies and the coalescent process in Oxford Surveys in Evolutionary Biology (vol. 7). Edited by D. Futuyma and J. Antonovics. Published by Oxford University Press, New York.

Marjoram P and Tavare S (2006) Modern computational approaches for analysing molecular genetic variation data. Nature Reviews Genetics 7:759-770

Schaffner SF, Foo C, Gabriel S, Reich D, Daly MJ and Altshuler D (2005) Calibrating a coalescent simulation of human genome sequence. Genome Research 15:1576-83