Biostatistics 666: Modeling Variation in the Coalescent

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Objective

This class builds on previous descriptions of the coalescent. In the class we model the impact of mutations on the coalescent and use it to study:

  • What is the expected frequency spectrum of neutral variants?
  • What is the distribution of S, the expected number variants discovered, after sequencing N samples.

Slides

Slides in PDF format

Recommended Reading

Richard R. Hudson (1990) Gene genealogies and the coalescent process in Oxford Surveys in Evolutionary Biology (vol. 7). Edited by D. Futuyma and J. Antonovics. Published by Oxford University Press, New York.