Difference between revisions of "Main Page"

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== Sequence Analysis Tools ==
 
== Sequence Analysis Tools ==
  
We are developing several tools for the analysis of next generation sequence data.  
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We are developing [[Software]] for the analysis of next generation sequence data.  
  
=== [[Read Mapping]] ===
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# Read Mapping with [[Karma]]
 
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# Variant Calling with [[glfSingle]], [[glfTrio]] and [[glfMultiples]]
[[Karma|Karma]] - Our fast short read aligner, which generates [[Mapping Quality Scores]]
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# Variant Annotations using [[vcfCodingSnps]]
 
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# Quality control using [[FastQValidator]], and [[BamIdentityCheck]]
[[Karma-colorspace|Karma-ColorSpace]] - QUICKSTART on mapping color space reads
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# File Readers using [[C++ Library: libbam|BamFile]] and [[C++ Library: libfqf|FastQFile]]
 
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# File Conversions using [[bam2FastQ]]
[[Examples|Examples]] - Sample command lines with discussion
 
 
 
[[MapabilityScores]] - Definitions of various mappability scores adopted at UCSC genome browser.
 
 
 
=== Variant Calling ===
 
 
 
[[glfSingle]] - Variant calling for a single, deeply sequenced individual
 
 
 
[[glfTrio]] - Variant calling for a single, deeply sequenced nuclear family with two parents and one child
 
 
 
[[glfMultiples]] -- Variant calling for multiple, unrelated individuals
 
 
 
=== Variant Annotation ===
 
 
 
[[vcfCodingSnps]] -- Annotate coding variants in a VCF file.
 
 
 
=== Quality Control Utilities ===
 
 
 
[[C++ Executable: fastQValidator|FastQValidator]] -- Check that a FASTQ file conforms to specification.
 
 
 
[[BamIdentityCheck]] -- Check that mapped reads are consistent with known genotypes for each individual.
 
 
 
=== File Readers ===
 
[[C++ Library: libbam|BamFile]] -- Reads a BAM/SAM file. 
 
 
 
[[C++ Library: libfqf|FastQFile]] -- Read a FASTQ file sequence by sequence.  Validating the sequence as it is read.
 
 
 
=== File Conversion ===
 
[[bam2FastQ]] -- Convert BAM files into FastQ files
 
=== [[Links to Sequence Analysis Tools|Other Useful Links]] ===
 
  
 
== Projects  ==
 
== Projects  ==

Revision as of 12:22, 8 April 2010

Abecasis Group Wiki


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Welcome!

Welcome to our brand new wiki!

If you would like to contribute, log-in or create an account. We recommend using your e-mail address or Michigan uniqname as your user id.

For basic instructions, see the Wikipedia Tutorial.

Sequence Analysis Tools

We are developing Software for the analysis of next generation sequence data.

  1. Read Mapping with Karma
  2. Variant Calling with glfSingle, glfTrio and glfMultiples
  3. Variant Annotations using vcfCodingSnps
  4. Quality control using FastQValidator, and BamIdentityCheck
  5. File Readers using BamFile and FastQFile
  6. File Conversions using bam2FastQ

Projects

SardiNIA - The SardiNIA longitudinal study of aging.

1000 Genomes Project Pilot 1 SNP Calling

Learn Genetics

Faculty in the group teach in a variety of formal and informal settings. Class notes and relevant discussion are archived here.

Abecasis Group Meeting

2:30-4:00 p.m. on Fridays, room 2610, SPH I. Please note April 9, please use room 2690, SPH I.

GoncaloAbecasis.jpg