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Biostatistics 666: Analysis of Low Pass Sequence Data

Objective

Discussion of the challenges involved in sequencing thousands of individual genomes. Introduction to the analysis of low pass sequence data.

Lecture Notes

Recommended Reading

  • The 1000 Genomes Project (2010) A map of human genome variation from population-scale sequencing. Nature 467:1061-73
  • Li Y, Willer CJ, Ding J, Scheet P and Abecasis GR (2010) MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol 34:816-834
  • Le SQ and Durbin R (2010) SNP detection and genotyping from low-coverage sequencing data on multiple diploid samples. Genome Research (in press)