Difference between revisions of "Biostatistics 666: Association Tests in Structured Populations"
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*Methods for Inferring Population Structure | *Methods for Inferring Population Structure | ||
**Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959 | **Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959 | ||
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| + | * Principal Components Analysis | ||
| + | ** Price et al (2006) Nature Genetics 38:904-909 | ||
*Transmission Disequilibrium Tests | *Transmission Disequilibrium Tests | ||
**Spielman et al (1993) Am J Hum Genet 52:506-16 (trios) | **Spielman et al (1993) Am J Hum Genet 52:506-16 (trios) | ||
**Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs) | **Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs) | ||
Revision as of 04:28, 26 October 2010
Overview
This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses three possible strategies for handling population structure, specifically:
- Using family based association tests, such as the TDT.
- Controling the overall inflation of test statistics, using the genomic control method.
- Using genotype based matching approaches.
Lecture Notes
Recommended Reading
- Genomic Control for Association Studies
- Devlin and Roeder (1999) Biometrics 55:997-1004
- Pritchard and Rosenberg (1999) Am J Hum Genet 65:220-228
- Methods for Inferring Population Structure
- Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959
- Principal Components Analysis
- Price et al (2006) Nature Genetics 38:904-909
- Transmission Disequilibrium Tests
- Spielman et al (1993) Am J Hum Genet 52:506-16 (trios)
- Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs)
