Biostatistics 666: Association Tests in Structured Populations

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Overview

This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses three possible strategies for handling population structure, specifically:

  • Using family based association tests, such as the TDT.
  • Controling the overall inflation of test statistics, using the genomic control method.
  • Using genotype based matching approaches.

Lecture Notes

Slides in PDF Format

Recommended Reading

  • Genomic Control for Association Studies
    • Devlin and Roeder (1999) Biometrics 55:997-1004
    • Pritchard and Rosenberg (1999) Am J Hum Genet 65:220-228
  • Methods for Inferring Population Structure
    • Pritchard, Stephens and Donnelly, 2000. Genetics 155: 945-959
  • Transmission Disequilibrium Tests
    • Spielman et al (1993) Am J Hum Genet 52:506-16 (trios)
    • Curtis (1997) Ann Hum Genet 61:319-33 (sibling pairs)
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