Biostatistics 666: Genotype Imputation

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Overview

Genotype imputation is one of the most commonly used tools for the analysis of genomewide association studies. This lecture introduces the basic ideas behind genotype imputation, together with some examples of its practical applications.

Slides

Slides in PDF Format

Recommended Reading

  • Chen and Abecasis (2007) Family based association tests for genome wide association scans. Am J Hum Genet 81:913-926
  • Li et al (2010) Using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genetic Epidemiology 34:816-834