Difference between revisions of "Biostatistics 666: Hardy-Weinberg Equilibrium"
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== Slides == | == Slides == | ||
| − | [[Media:666.02. | + | [[Media:666.2017.02 - Hardy Weinberg Equilibrium.pdf|Slides in PDF format]] |
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| + | [[Media:666.02.pdf|Previous version]] | ||
== Background Reading == | == Background Reading == | ||
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Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. ''Am J Hum Genet'' '''76''':887-93 | Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. ''Am J Hum Genet'' '''76''':887-93 | ||
| + | [http://www.sph.umich.edu/csg/abecasis/publications/15789306.html Abstract and PDF] | ||
Latest revision as of 08:30, 11 September 2017
Objective
The objective of this lecture is to introduce the concept of Hardy Weinberg equilibrium. Hardy Weinberg equilibrium is a property of genetic data that allows us to parsimoniously describe genotype frequencies in a population. The reasons why Hardy Weinberg equilibrium generally holds, common reasons for deviation from Hardy Weinberg equilibrium, and methods for checking for significant deviations from Hardy-Weinberg equilibrium will all be discussed.
Slides
Background Reading
Please read the following paper:
Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 76:887-93 Abstract and PDF
