Difference between revisions of "Biostatistics 666: Hardy-Weinberg Equilibrium"
From Genome Analysis Wiki
Jump to navigationJump to searchLine 12: | Line 12: | ||
Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. ''Am J Hum Genet'' '''76''':887-93 | Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. ''Am J Hum Genet'' '''76''':887-93 | ||
+ | [http://www.sph.umich.edu/csg/abecasis/publications/15789306.html Abstract and PDF] |
Revision as of 22:37, 8 September 2010
Objective
The objective of this lecture is to introduce the concept of Hardy Weinberg equilibrium. Hardy Weinberg equilibrium is a property of genetic data that allows us to parsimoniously describe genotype frequencies in a population. The reasons why Hardy Weinberg equilibrium generally holds, common reasons for deviation from Hardy Weinberg equilibrium, and methods for checking for significant deviations from Hardy-Weinberg equilibrium will all be discussed.
Slides
Background Reading
Please read the following paper:
Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 76:887-93 Abstract and PDF