# Difference between revisions of "Biostatistics 666: Hardy-Weinberg Equilibrium"

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== Objective == | == Objective == | ||

− | The objective of this lecture is to introduce the concept of Hardy Weinberg equilibrium. Hardy Weinberg equilibrium is a property of genetic data that allows us to parsimoniously describe genotype frequencies in a population. The reasons why Hardy Weinberg equilibrium generally holds, common reasons for deviation from Hardy Weinberg equilibrium, and methods for checking for significant deviations from Hardy-Weinberg equilibrium. | + | The objective of this lecture is to introduce the concept of Hardy Weinberg equilibrium. Hardy Weinberg equilibrium is a property of genetic data that allows us to parsimoniously describe genotype frequencies in a population. The reasons why Hardy Weinberg equilibrium generally holds, common reasons for deviation from Hardy Weinberg equilibrium, and methods for checking for significant deviations from Hardy-Weinberg equilibrium will all be discussed. |

== Slides == | == Slides == |

## Revision as of 02:49, 12 January 2010

## Objective

The objective of this lecture is to introduce the concept of Hardy Weinberg equilibrium. Hardy Weinberg equilibrium is a property of genetic data that allows us to parsimoniously describe genotype frequencies in a population. The reasons why Hardy Weinberg equilibrium generally holds, common reasons for deviation from Hardy Weinberg equilibrium, and methods for checking for significant deviations from Hardy-Weinberg equilibrium will all be discussed.

## Slides

## Background Reading

Please read the following paper:

Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. *Am J Hum Genet* **76**:887-93