# Biostatistics 666: Hardy-Weinberg Equilibrium

From Genome Analysis Wiki

## Objective

The objective of this lecture is to introduce the concept of Hardy Weinberg equilibrium. Hardy Weinberg equilibrium is a property of genetic data that allows us to parsimoniously describe genotype frequencies in a population. The reasons why Hardy Weinberg equilibrium generally holds, common reasons for deviation from Hardy Weinberg equilibrium, and methods for checking for significant deviations from Hardy-Weinberg equilibrium will all be discussed.

## Slides

## Background Reading

Please read the following paper:

Wigginton JE, Cutler DJ and Abecasis GR (2005). A note on exact tests of Hardy-Weinberg equilibrium. *Am J Hum Genet* **76**:887-93
Abstract and PDF