Biostatistics 666: Introduction to the Coalescent
From Genome Analysis Wiki
Objective
Introduce the coalescent as a practical means to model the properties of alleles in a population.
The coalescent is an extremely convenient modeling tool for studying population genetic properties, such as the number of variants in region, their allele frequencies and linkage disequilibrium relationships between them. We'll discuss the advantages of the coalescent relative to alternatives such as forward simulation and introduce some of the properties of genetic variation that can be studied with the coalescent.
Slides
Background Reading
Richard R. Hudson (1990) Gene genealogies and the coalescent process in Oxford Surveys in Evolutionary Biology (vol. 7). Edited by D. Futuyma and J. Antonovics. Published by Oxford University Press, New York.
