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Biostatistics 666: Linkage Analysis in Sibling Pairs


This lecture introduces Neil Risch's Maximum Lod Score (MLS) test for linkage and its refinement using Peter Holman's possible triangle constraint.


Recommended Reading

Risch (1990) Linkage Strategies for Genetically Complex Traits. III. The Effect of Marker Polymorphism on Analysis of Affected Relative Pairs. Am J Hum Genet 46:242-253

Risch (1990) Linkage strategies for genetically complex traits. I. Multi-locus models. Am J Hum Genet 46:222-228

Holmans (1993) Asymptotic Properties of Affected-Sib-Pair Linkage Analysis. Am J Hum Genet 52:362-374