Difference between revisions of "Biostatistics 666: Linkage Tests for Pairs of Individuals"
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== Recommended Reading == | == Recommended Reading == | ||
| − | Bishop DT and Williamson JA (1990)''Am J Hum Genet'' '''46''':254-265 | + | Bishop DT and Williamson JA (1990) ''Am J Hum Genet'' '''46''':254-265 |
Risch (1990) ''Am J Hum Genet'' '''46''':242-253 | Risch (1990) ''Am J Hum Genet'' '''46''':242-253 | ||
Revision as of 07:15, 23 March 2010
Overview
This lecture introduces simple linkage tests in the context of affected sibling pairs. One test, originally described by Bishop and Williamson (1990) focuses on identity-by-state sharing. A more refined test, introduced by Risch (1990), models IBD information using a likelihood approach.
Lecture Notes
Recommended Reading
Bishop DT and Williamson JA (1990) Am J Hum Genet 46:254-265
Risch (1990) Am J Hum Genet 46:242-253
