Difference between revisions of "Biostatistics 666: Maximum Likelihood Allele Frequency Estimation"

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== Slides ==
== Slides ==
* [[Media:666.09.pdf|Handouts in PDF format]] - Solutions to in class exercises are left blank.
* [[Media:666.2017.07 - Maximum Likelihood Estimation.pdf|Slides in PDF format]]
* [[Media:666.09.Master.pdf|Lecturer's Slides in PDF format]] - This version includes solutions to in class exercise.
== Recommended Reading ==
== Recommended Reading ==

Latest revision as of 06:52, 2 October 2017


This lecture examines maximum likelihood based estimation of allele frequencies in several simple settings, such as estimation of allele frequencies from samples of unrelated individuals and from samples of mother-child pairs. The objective is to both provide an intuition to some of the issues involved in allele frequency estimation but also to review the basic principles of maximum likelihood estimation.


Recommended Reading

For a review of the principles of maximum likelihood estimation, see an introductory statistics text, such as:

Garthwaite, Jolliffe, Jones (1995) Statistical Inference. Prentice Hall, Hertfordshire (UK)