Difference between revisions of "Biostatistics 666: Modeling Variation in the Coalescent"

From Genome Analysis Wiki
Jump to: navigation, search
(Slides)
(Slides)
 
Line 8: Line 8:
 
== Slides ==
 
== Slides ==
  
[[Media:666.05.pdf|Slides in PDF format]]
+
[[Media:666.2017.05_-_Coalescent_and_Allele_Counts.pdf|Slides in PDF format]]
  
 
== Recommended Reading ==
 
== Recommended Reading ==

Latest revision as of 08:26, 25 September 2017

Objective

This class builds on previous descriptions of the coalescent. In the class we model the impact of mutations on the coalescent and use it to study:

  • What is the expected frequency spectrum of neutral variants?
  • What is the distribution of S, the expected number variants discovered, after sequencing N samples.

Slides

Slides in PDF format

Recommended Reading

Richard R. Hudson (1990) Gene genealogies and the coalescent process in Oxford Surveys in Evolutionary Biology (vol. 7). Edited by D. Futuyma and J. Antonovics. Published by Oxford University Press, New York.