Biostatistics 666: Modeling Variation in the Coalescent

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Objective

This class builds on previous descriptions of the coalescent. In the class we model the impact of mutations on the coalescent and use it to study:

  • What is the expected frequency spectrum of neutral variants?
  • What is the distribution of S, the expected number variants discovered, after sequencing N samples.

Slides

Slides in PDF format

Recommended Reading

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