Biostatistics 666: Power of Genomewide Association Studies

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Objective

This lecture discusses power calculations in the context of genomewide association studies. It also introduces the concept of two stage designs and the tradeoffs between replication based and two stage analyses. The "Winner's Curse" makes a brief cameo appearance.

Lecture Notes

Slides in PDF Format

Recommended Reading

Skol el al (2006) Joint analysis is more efficient than replication based analysis for two-stage genomewide association studies. Nature Genetics 38:209-13