Difference between revisions of "Fst"
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== Formulae == | == Formulae == | ||
| + | |||
| + | For the simple case of two populations, this is simply: | ||
| + | |||
| + | :<math>F_{st} = (p_1 - p_2)^2 / {2\overline{p}(1-\overline{p})}</math> | ||
| + | |||
| + | Where: | ||
| + | |||
| + | :<math>\overline{p} = (p_1 + p_2) / 2</math> | ||
== References == | == References == | ||
| − | Nielsen R, Mountain JL, Huelsenbeck JP | + | Nielsen R, Mountain JL, Huelsenbeck JP and Slatkin M (1998) Maximum-Likelihood Estimation of Population Divergence Times and Population Phylogeny in Models Without Mutation. ''Evolution'' '''52''':669-677 |
| + | |||
| + | Reynolds J, Weir BS and Cockerham CC (1983) Estimation of the coancestry coefficient: basis for a short-term genetic distance. ''Genetics'' '''105''':767-779. | ||
Latest revision as of 03:47, 3 October 2010
Fst is a measure of population divergence. It measures the reduction in heterozygosity in a subdivided population compared to that in large, random mating population with the same allele frequencies.
Formulae
For the simple case of two populations, this is simply:
Where:
References
Nielsen R, Mountain JL, Huelsenbeck JP and Slatkin M (1998) Maximum-Likelihood Estimation of Population Divergence Times and Population Phylogeny in Models Without Mutation. Evolution 52:669-677
Reynolds J, Weir BS and Cockerham CC (1983) Estimation of the coancestry coefficient: basis for a short-term genetic distance. Genetics 105:767-779.
