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Equivalently, you could write -d reference.dat,sample.dat -p reference.ped,sample.ped on the command line and MACH would merge both files ''on-the-fly''.
Equivalently, you could write -d reference.dat,sample.dat -p reference.ped,sample.ped on the command line and MACH would merge both files ''on-the-fly''.
=== '''How long does imputation take?''' ===
=== '''How long does imputation take?''' ===
A: The following factors/parameters affect computational time:
#m, # of genotyped markers (number of markers in .dat file)<br>
#n, # of individuals<br>
#h, # of reference haplotypes (determined by --greedy or states, by default, h = 2*number diploid individuals - 2 + number_haplotypes)<br>
#r, # of rounds (-r or --rounds, --mle corresponds to 1-2 rounds)
Computational time increases linearly with m, n, r and quadratically with h. On our Xeon 3.0GHz machine, imputation with m=25K, n=250, h=120, and r=100 takes ~20 hours. <br>
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=== '''More questions?''' ===
=== '''More questions?''' ===
