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MaCH: machX

Revision as of 09:42, 26 November 2010 by Ylwtx (talk | contribs)

This page documents how to perform X chromosome (non-pseudo-autosomal part) imputation using MaCH [1] and minimac [2].


Getting Started

Your Own Data

To get started, you will need to store your data in Merlin format pedigree and data files, one per chromosome. For details of the Merlin file format, see the Merlin tutorial [http:/].

Within each file, markers should be stored by chromosome position. Alleles should be stored in the forward strand and can be encoded as 'A', 'C', 'G' or 'T' (there is no need to use numeric identifiers for each allele).

Note that for males hemizygotes are coded as homozygotes.

Reference Haplotypes

You can download the following reference haplotypes from MaCH download page [3].

Two-Step Imputation

Phase Your Own Data