minimac is a low memory, computationally efficient implementation of the MaCH algorithm for genotype imputation. It is designed to work on phased genotypes and can handle very large reference panels with hundreds or thousands of haplotypes. The name has two parts. The first, "mini", refers to the modest amount of computational resources it requires. The second, "mac", is short hand for MaCH, our widely used algorithm for genotype imputation.
A good rule of thumb is that minimac should take about 1 hour to impute 1,000,000 markers in 1,000 individuals using a reference panel with 100 haplotypes. Performance should increase linearly with respect to all these factors. So, if you have M markers to impute in N individuals and a reference panel with H haplotypes, your approximate computing time in hours should be about M * N * H * 10-11. These statistics refer to Intel X7460 CPU running at 2.66 GHz and your mileage may vary; most modern CPUs should be no more than a few times faster (or slower) than that.
A public release of
minimac is expected here by October 1, 2010.
If you are looking to learn about small computers made by Apple, Inc., you have come to the wrong page. Try looking at http://www.apple.com/macmini/, instead.
If you are looking for a low calorie version of the Big Mac sandwich, you'll be sad to know the Mini Mac has been discontinued. However, you are not the only one who likes the idea of a Mini Mac and you'll probably find some company on the web .