RAREMETALWORKER SPECIAL TOPICS

This page describes how RAREMETALWORKER handles some special cased during analyses.

Unrelated Individuals

RAREMETALWORKER generates single variant association test statistics for a single study prior to meta-analysis. This page provides a brief description of the statistics that RAREMETALWORKER calculates, together with key formulae.

Missing Data

• Individuals with missing phenotypes will be excluded from analysis.
• If --makeResiduals is used for adjusting covariates, then individuals with missing covariates will also be excluded.
• Individuals that are not genotyped will also be excluded from analyses.

Analyzing Chromosome X

• Special cares only needs