RAREMETAL Change Log

• Version 4.13.7 released. (9/18/2015).
  • use -O0 option in compiling. In very rare situations, gcc optimization will affect the results.
  • tabix RMW output with --zip toggled.
  • In SKAT meta analysis, skip the variant when all its lambdas are zero.
  • bug fixes in conditional analysis.
  • generate group file if group from vcf.
  • add --altMAF option.

• Version 4.13.6 released. (3/8/2015)
  • add a new option --mergedVCFID to recognize VCF files with sample IDs in "FAMID_PID" format, and another new option --flagDosage to flag the field name to label dosage in VCF file.

• Version 4.13.5 released. (9/29/2014)
  • a bug fixed in conditional analysis in raremetal.

• Version 4.13.4 released.
  • store beta estimates of intercept and fixed effects in rarmetalworker *.singlevar.score.txt header.

• Version 4.13.3 released.
  • read rvtest output format correctly in raremetal.

• Version 4.13.2.
  • fixed sqrt_V output when analyzing unrelated individuals without kinship and --inverseNormal is not used and trait variance is not one.

• Version 4.13.1.
  • fixed a bug affecting output format when ped/dat files are used together with --dominant --recessive options.

• version 4.13
  • fixed bug when using --vcX option.
  • Fixed bug estimating kinshipX with female samples.
  • Added --kinOnly option for generating kinship only without association analysis.
  • Added --geneMap option to allow user input for gene-mapping file.

• version 4.12.1
  • fixed command interface display issue in raremetalworker.

• version 4.12
  • improved make file for better compilation.

• version 4.11
  • fixed a bug for inverse-normalizing traits (a bug only in version 4.9 and later).

• version 4.10
  • fixed a bug when analyzing multiple traits is requested in raremetalworker (bug only in version 4.9 and later, and doesn't affect results).

Version 4.8 and before

• Merged raremetal and raremetalworker in one package following version number of raremetalworker. Completed testing compiling on various platforms. (4/22/14)
• Version 0.4.4 released with a bug fixed when alleles are flipped in group file. (3/14/2014)
• Version 0.4.2 released with a bug fixed for SKAT when there are two variants in a group, and a bug fixed in Makefile for easy compiling.
• Version 0.4.0 released with a few bugs fixed to properly handling missing genotypes. Major change in command options. Now allow user to specify list of summary statistics files and covariance files separately using --summaryFiles and --covFiles options.
• Version 0.3.1 released to fix a bug when one of the alleles coded as missing.
• Version 0.2.9 released after fixing a bug in SKAT and writing PDF when all variants are monomorphic. (10/7/2013)
• Version 0.1.2 released after fixing a few bugs, adding conditional analysis and automatic graphing to the tool. (8/5/2013)
• Version 0.0.1 released. (2/24/2013)
• Version 0.0.1 released to U of M CSG group. (2/13/2013)

• Released version 0.4.7 binary and source code. Optimized code to increase analysis efficiency and reduce memory use. Added --separateX option to provide another choice of analyzing chromosome X. Added --kinxFile option to allow kinship X matrix file with different prefix from the autosomal kinship.(4/2/2014)
• Released version 0.4.6 binary. Fixed a bug in recessive and dominant results. (4/1/2014)
• Released version 0.4.5. Fixed a bug when generating plots for recessive results. (3/18/2014)
• Released version 0.4.4. Fixed hwe=0.0 issue for monomorphic sites. (3/17/2014)
• Released version 0.4.3. Fixed a few typo in messages. Added --noeof option for VCF files that does not have a BGZF EOF marker.
• Released version 0.4.2. Fixed a bug that could possibly cause compiling error in some Linux system. Also, in this version, male heterozygous genotypes on chromosome X are considered missing. (3/10/2014)
• Released version 0.4.1. Fixed a bug handling variants in nonPAR region on chromosome X when all samples are male.
• Released version 0.4.0. Added phone home function. Saved Recessive and dominant results in separate files.
• Released version 0.3.7. Added dominant and recessive models as options. The default model is additive. (1/7/2014)
• Released version 0.3.6 and fixed a minor bug that caused by code upgrades from version 0.3.5. (12/4/2013)
• Fixed a few bugs handling chromosome X. Generated warning messages when male genotypes are coded wrong in VCF file. (11/25/2013)
• Fixed the bug which causes crash when writing PDF when all variants are monomorphic. (10/6/2013)
• Added support for analyzing dosages from VCF in version 2.9. (8/27/2013)
• Fixed bug in handling chromosome X. Added sanity checking steps before analysis. Added graphic support by generating QQ and manhattan plots automatically. Upgraded tool to version 2.8. (till 8/12/2013)
• Updated code to report allele frequencies calculated only from selected samples. (3/3/2013)
• Optimized code to speed up the process of calculating empirical kinship. (3/3/2013)
• Fixed a bug when handling chromosome X. Added sex labels option. (3/2/2013)
• Fixed a bug when there is missing genotype from VCF file. (2/2013)
• Fixed a bug when reading vcf file with ref or alt allele is missing. (2/5/2013)
• Changed executable name into bin/raremetalworker. Version 0.0.7 released. (12/10/2012)
• Updated output format for monomorphic sites. (12/7/2012)
• Version 0.0.6 released. (12/6/2012)
• Bug fixed for empirical kinship calculation when genotypes are read from VCF file. Version 0.0.5 released. (12/6/2012)
• Version 0.0.4 released. (12/5/2012)
• More messages coded into log file. (12/4/2012)
• Updated output format. Version 0.0.3 released. (12/3/2012)
• Bugs fixed to solve compiling errors on some machines (Thank you Mary Kate!). Version 0.0.2 released. (11/30/2012)
• Added HWE pvalue and call rate in summary statistics output. (11/27/2012)
• Forced sample IDs to be matched when reading in kinship from a file. Perform a sanity check before reading in kinship file. If a sample of interest is not included in kinship file, then fatal error will occur. (11/19/2012)
• Enabled writing log file by defalut. (11/18/2012)
• Uploaded to public wiki. (11/16/2012)
• Modified Rare-Metal-Worker to let it output LD matrix by a sliding window. (11/14/2012)
• Version 0.0.1 was released on 11/13/2012.