Changes

* '''Rare Metal''' also has the option of generating a VCF file according to the pooled information from individuals studies. Then user can use their favorite annotation tools to annotate the VCF file into the INFO field. Currently, '''Rare Metal''' only support limited formats of annotated VCF file.  

* '''Rare Metal''' also has the option of generating a VCF file according to the pooled information from individuals studies. Then user can use their favorite annotation tools to annotate the VCF file into the INFO field. Currently, '''Rare Metal''' only support limited formats of annotated VCF file.  

* A more flexible way, which is also a recommended way, is to generate a group file from the customized annotated VCF file and use that as input to '''Rare Metal'''.

* A more flexible way, which is also a recommended way, is to generate a group file from the customized annotated VCF file and use that as input to '''Rare Metal'''.

* For formats of annotated VCF that '''Rare Metal''' currently support, please refer to the following:

* For formats of annotated VCF that '''Rare Metal''' currently support, please refer to the following [http://genome.sph.umich.edu/wiki/Rare-Metal#Grouping_from_an_Annotated_VCF_File | annotated VCF]:

'''NOTE:''' if no grouping method is provided, then only single variant meta analysis will be performed.

'''NOTE:''' if no grouping method is provided, then only single variant meta analysis will be performed.