2,004
edits
Changes
From Genome Analysis Wiki
Jump to navigationJump to search→BURDEN META ANALYSIS
===BURDEN META ANALYSIS===
===BURDEN META ANALYSIS===
Once single variant meta analysis statistics are constructed, weighted burden test score statistic can be easily reconstructed as
Once single variant meta analysis statistics are constructed, burden test score statistic can be easily reconstructed as
<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>
<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>
