Changes

===BURDEN META ANALYSIS===

===BURDEN META ANALYSIS===

Once single variant meta analysis statistics are constructed, burden test score statistic can be easily reconstructed as

 

Burden test has been shown to be powerful detecting a group of rare variants that are unidirectional in effects. Once single variant meta analysis statistics are constructed, burden test score statistic can be easily reconstructed as

<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>.

<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>.