Changes

===BURDEN META ANALYSIS===

===BURDEN META ANALYSIS===

Burden test has been shown to be powerful detecting a group of rare variants that are unidirectional in effects. Once single variant meta analysis statistics are constructed, burden test score statistic can be easily reconstructed as

Burden test has been shown to be powerful detecting a group of rare variants that are unidirectional in effects. Once single variant meta analysis statistics are constructed, burden test score statistic for a gene can be easily reconstructed as

<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>.

<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>,

 

where <math>\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m})</math>, representing a vector of single variant meta-analysis scores of <math>m</math> variants in a gene.

===VT META ANALYSIS===

===VT META ANALYSIS===