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<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>,
<math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>,
where <math>\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m})</math>, representing a vector of single variant meta-analysis scores of <math>m</math> variants in a gene.
where <math>\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m}) and \mathbf{V_meta}=cov(\mathbf{U_{meta}}</math>, representing a vector of single variant meta-analysis scores of <math>m</math> variants in a gene and the covariance matrix of the scores across <math>m</math> variants.
===VT META ANALYSIS===
===VT META ANALYSIS===
