# Difference between revisions of "RAREMETAL METHOD"

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Shuang Feng (talk | contribs) m (Shuang Feng moved page RAREMETAL method to RAREMETAL METHOD) |
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+ | ==INTRODUCTION== | ||

The key idea behind meta-analysis with RAREMETAL is that various gene-level test statistics can be reconstructed from single variant score statistics and that, when the linkage disequilibrium relationships between variants are known, the distribution of these gene-level statistics can be derived and used to evaluate signifi-cance. Single variant statistics are calculated using the Cochran-Mantel-Haenszel method. The main formulae are tabulated in the following: | The key idea behind meta-analysis with RAREMETAL is that various gene-level test statistics can be reconstructed from single variant score statistics and that, when the linkage disequilibrium relationships between variants are known, the distribution of these gene-level statistics can be derived and used to evaluate signifi-cance. Single variant statistics are calculated using the Cochran-Mantel-Haenszel method. The main formulae are tabulated in the following: | ||

+ | |||

+ | ==KEY FORMULAE== | ||

+ | |||

+ | ===SINGLE VARIANT META ANALYSIS=== | ||

+ | |||

+ | ===BURDEN META ANALYSIS=== | ||

+ | |||

+ | ===VT META ANALYSIS=== | ||

+ | |||

+ | ===SKAT META ANALYSIS=== | ||

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## Revision as of 14:22, 1 April 2014

## Contents

## INTRODUCTION

The key idea behind meta-analysis with RAREMETAL is that various gene-level test statistics can be reconstructed from single variant score statistics and that, when the linkage disequilibrium relationships between variants are known, the distribution of these gene-level statistics can be derived and used to evaluate signifi-cance. Single variant statistics are calculated using the Cochran-Mantel-Haenszel method. The main formulae are tabulated in the following:

## KEY FORMULAE

### SINGLE VARIANT META ANALYSIS

### BURDEN META ANALYSIS

### VT META ANALYSIS

### SKAT META ANALYSIS

Test | Statistics | Null Distribution | Notation |
---|---|---|---|

Single Variant | |||

un-weighted Burden | |||

Weighted Burden | |||

VT | |||

SKAT |