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, 00:24, 9 April 2014
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| <math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>, | | <math>T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)</math>, |
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− | where <math>\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m})</math> and <math> \mathbf{V_{meta}}=cov(\mathbf{U_{meta}})</math>, representing a vector of single variant meta-analysis scores of <math>m</math> variants in a gene and the covariance matrix of the scores across <math>m</math> variants. | + | where <math>\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m})^T</math> and <math> \mathbf{V_{meta}}=cov(\mathbf{U_{meta}})</math>, representing a vector of single variant meta-analysis scores of <math>m</math> variants in a gene and the covariance matrix of the scores across <math>m</math> variants. |
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| ===VT META ANALYSIS=== | | ===VT META ANALYSIS=== |