Raremetal Incoming updates

From Genome Analysis Wiki
Jump to navigationJump to search

Main Wiki Page

Finished in test version

  • Optimization for unbalanced studies (Jingjing Yang)

Incoming update

  • Add an option to store group file from vcf
  • Take snpeff as annotation input
  • When no conditional variant is available, warning is generated but not written to log file.
  • SKAT conditional analysis misses the last 3 column names. They should be cond_statistics, cond_pvalue_davis, cond_p_value_liu.
  • enable reading from .gz annotated vcf
  • add SKAT-O
  • solve the numeric issue of lambda = 0 in SKAT
  • In conditional analysis, when cov matrix between the test variant and its conditioned variants is not invertible, MathSVD still tries to invert that matrix and that leads to weird conditional p values.