Open main menu

Genome Analysis Wiki β

Changes

RAREMETAL METHOD

85 bytes added, 14:35, 27 November 2016
SINGLE VARIANT META ANALYSIS
<math>T_{meta_i}=U_{meta_i}\bigg/\sqrt{V_{meta_i}}=\sum_{k=1}^S {U_{i,k}}\bigg/\sqrt{\sum_{k=1}^S{V_{ii,k}}} \sim\mathbf{N}(0,1)</math>.
 
'''Optimized method for unbalanced studies (--useExact)''':
<math>U_{meta_i}=\sum_{k=1}^S {U_{i,k}/\hat{\Omega_{k}}}-\sum_{k=1}^S{2n_{k}{\delta_{k}(f_{i}-f_{i,k})}}</math>
 
<math>V_{meta_i}={\sigma^{2}}\sum_{k=1}^S{V_{ii,k}-4n_{k}(ff'-f_{k}f_{k}')}</math>
===BURDEN META ANALYSIS===
271
edits