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== Brief Description ==

== Brief Description ==

rareMETAL is a tool for meta-analysis rare variants from genotype arrays and sequencing. rareMETAL can combine summary statistics of individual studies generated by [[Rare-Metal-Worker|rareMetalWorker]]. It provides a convenient approach for both single variant and gene-level meta-analysis of rare variants from various studies, when joint-analysis of raw data from these studies are restricted.

'''rareMETAL''' is a computationally efficient tool for meta-analysis of rare variants using sequencing or genotyping array data. '''rareMETAL''' takes summary statistics and LD matrices generated by [[Rare-Metal-Worker|'''rareMetalWorker''']], handles related and unrelated individuals, and supports both single variant and burden meta-analysis. An R-package using the same methodology is [[RareMetals|available]]].

 

'''rareMETAL''' is developed by Shuang Feng, Dajiang Liu and Gonçalo Abecasis. Manuscript for this tool is in preparation. Please contact sfengsph at umich dot edu for questions.

== Approach ==

== Approach ==