Changes

===SKAT META ANALYSIS===

===SKAT META ANALYSIS===

SKAT has been powerful detecting genes with rare variants having opposite directions in effect sizes. Meta-analysis statistic can also be re-constructed using single variant meta-analysis scores and their covariances

SKAT is most powerful when detecting genes with rare variants having opposite directions in effect sizes. Meta-analysis statistic can also be re-constructed using single variant meta-analysis scores and their covariances

<math>\mathbf{Q}=\mathbf{{U_{meta}}^T}\mathbf{W}\mathbf{U_{meta}}</math>.  

<math>\mathbf{Q}=\mathbf{{U_{meta}}^T}\mathbf{W}\mathbf{U_{meta}}</math>.