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RAREMETAL METHOD

597 bytes added, 23:59, 8 April 2014
VT META ANALYSIS
where <math>j</math> represents any allele frequency in a group of rare variants, <math>\boldsymbol{\phi}_{f_j}</math> is a vector of 0 and 1, indicating if a variant is included in the analysis using frequency threshold <math>f_i</math>.
 
As described by Lin et. al, the null distribution of the test statistic can be
 
<math> \left(T_{b\left(f_1\right)},T_{b\left(f_2\right)},\dots,T_{b\left(f_m\right)}\right)</math><math>\sim\mathbf{MVN}\left(\mathbf{0},\boldsymbol{\Omega}\right)\text{,} </math><math>\text{where }\boldsymbol{\Omega_{ij}}=\frac{\boldsymbol{\phi}_{f_i}^T\left(\sum_{i=1}^n{\mathbf{V_i}}\right)\boldsymbol{\phi}_{f_j}}{\sqrt{\boldsymbol{\phi}_{f_i}^T\left(\sum_{i=1}^n{\mathbf{V_i}}\right)\boldsymbol{\phi}_{f_i}}\sqrt{\boldsymbol{\phi}_{f_j}^T\left(\sum_{i=1}^n{\mathbf{V_i}}\right)\boldsymbol{\phi}_{f_j}}}</math>
===SKAT META ANALYSIS===
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