# Changes

## RAREMETAL METHOD

, 00:20, 9 April 2014
BURDEN META ANALYSIS
===BURDEN META ANALYSIS===
Burden test has been shown to be powerful detecting a group of rare variants that are unidirectional in effects. Once single variant meta analysis statistics are constructed, burden test score statistic for a gene can be easily reconstructed as
$T_{meta_{burden}}=\mathbf{w^TU_{meta}}\bigg/\sqrt{\mathbf{w^TV_{meta}w}} \sim\mathbf{N}(0,1)$, where $\mathbf{U_{meta}} = (U_{meta_1},U_{meta_2},...,U_{meta_m})$, representing a vector of single variant meta-analysis scores of $m$ variants in a gene.
===VT META ANALYSIS===
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