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, 07:59, 27 June 2014
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| ** direction.by.study: Direction of genetic effects by study | | ** direction.by.study: Direction of genetic effects by study |
| ** anno: Annotation for variants | | ** anno: Annotation for variants |
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| + | == Perform single variant association test using a group file == |
| + | Summary level statistics collected in meta-analysis can often be messy, messier for lower frequency variants than for common variants. To correct for the right alleles, and make sure that ref/alt alleles from each study are properly aligned, it is often desirable to |
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| == Performing gene level association test == | | == Performing gene level association test == |
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| ** direction.meta.single.var.out: Direction of meta-analysis statistics for single variant test. It may be useful for inspecting if any of the variant in the gene have opposite effects etc. | | ** direction.meta.single.var.out: Direction of meta-analysis statistics for single variant test. It may be useful for inspecting if any of the variant in the gene have opposite effects etc. |
| ** pos.ref.alt.out: Position, reference and alternative alleles for each variant position in the gene | | ** pos.ref.alt.out: Position, reference and alternative alleles for each variant position in the gene |
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| + | == Perform gene-level test with a group file == |
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| == Performing conditional analysis for single variant tests == | | == Performing conditional analysis for single variant tests == |