Changes

From Genome Analysis Wiki
Jump to navigationJump to search
386 bytes added ,  07:59, 27 June 2014
no edit summary
Line 48: Line 48:  
** direction.by.study: Direction of genetic effects by study
 
** direction.by.study: Direction of genetic effects by study
 
** anno: Annotation for variants
 
** anno: Annotation for variants
 +
 +
== Perform single variant association test using a group file ==
 +
Summary level statistics collected in meta-analysis can often be messy, messier for lower frequency variants than for common variants. To correct for the right alleles, and make sure that ref/alt alleles from each study are properly aligned, it is often desirable to
 +
    
== Performing gene level association test ==
 
== Performing gene level association test ==
Line 77: Line 81:  
** direction.meta.single.var.out: Direction of meta-analysis statistics for single variant test. It may be useful for inspecting if any of the variant in the gene have opposite effects etc.   
 
** direction.meta.single.var.out: Direction of meta-analysis statistics for single variant test. It may be useful for inspecting if any of the variant in the gene have opposite effects etc.   
 
** pos.ref.alt.out: Position, reference and alternative alleles for each variant position in the gene
 
** pos.ref.alt.out: Position, reference and alternative alleles for each variant position in the gene
 +
 +
== Perform gene-level test with a group file ==
 +
 +
    
== Performing conditional analysis for single variant tests ==
 
== Performing conditional analysis for single variant tests ==
131

edits

Navigation menu