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* Manuela Uda (National Research Center, Cagliari, Italy)
* Manuela Uda (National Research Center, Cagliari, Italy)
* Goncalo Abecasis (University of Michigan, Ann Arbor)
* Goncalo Abecasis (University of Michigan, Ann Arbor)
== Genomewide Association Study ==
We carried out an initial genomewide association by genotyping 1405 samples with Affymetrix 500K SNP arrays. Then, because SardiNIA samples are closely related to each other, we were able to use these genotypes to impute the genomes of many close relatives who were genotyped with Affymetrix 10K SNP arrays. Typically, our SardiNIA GWAS analysis thus include approximately 4300 genotyped or imputed individuals. To learn more about the approach see Chen and Abecasis (2007) and Scuteri et al (2007).
=== Planned Updates ===
Several ongoing experiments are expected to gradually improve our GWAS data. First, we expect to integrate Affymetrix 1M SNP chip genotypes into our analyses. Second, we plan to genotype all sampled individuals with the Metabochip, which includes 200,000 SNPs. This will enable us to fill in genotypes for relatives of those genotyped with denser arrays more accurately, because we will more precisely identify shared stretches of chromosome.
== Medical Sequencing Project ==
== Medical Sequencing Project ==
