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The R package rareMETALS2 was an extension of the R package rareMETALS. It was designed to meta-analyze gene-level association tests for '''binary trait''' . While rareMETALS offers a near-complete solution for meta-analysis of gene-level tests for quantitative trait, it does not offer the optimal solution for binary trait.
The package '''rareMETALS2''' is under development. It takes summary association statistics generated by rvtests as input. It offers the following unique features
* 1.) It allows the meta-analysis of samples with related individuals and samples with unrelated individuals, and allows
approximate estimate of genetic effect using
* 2.) It allows the adjustment of covariates in meta-analysis.
* 3.) It allows conditional meta-analysis of single variant and gene-level associations.
To install the package, please use "R CMD INSTALL rareMETALS2_XXX.tar.gz" command, where XXX is the version number for rareMETALS2