From Genome Analysis Wiki
Jump to navigationJump to search
2,319 bytes added
, 22:15, 19 July 2019
Line 75: |
Line 75: |
| | | |
| == Chunking Parameters == | | == Chunking Parameters == |
| + | Minimac4 automatically chunks the whole chromosome (into overlapping chunks), analyzes each chunk sequentially and then concatenates the imputed chunks back. |
| + | |
| + | ;--ChunkLengthMb <float_number> |
| + | : This option defines the average length of chunks in units of million base pairs (Mb). The input value should be within (0.001, 300]. The default setting is 20. |
| + | |
| + | ;--ChunkOverlapMb <float_number> |
| + | : This option defines the length of overlap between chunks in units of Mb, 3Mb by default. The valid input value should be within (0.001, 300]. |
| + | : The overlap length should be at most 1/3 of the chunk length, if larger, Minimac4 will automatically reduce it to 1/3 of the chunk length. |
| | | |
| == Subset Parameters == | | == Subset Parameters == |
| + | This set of parameters are used when imputing a specific region instead of all the sites covered by the reference panel. |
| + | |
| + | ; --chr <chromosome> |
| + | : This option specifies the chromosome number for which we will carry out imputation. |
| + | : Note that it is required to specify non-zero values for <code>--start</code> and <code>--end</code> when <code>--chr</code> option is used. |
| + | |
| + | ; --start <integer> |
| + | : This option specifies the start position of the region to be analyzed. Would not work without <code>--chr</code> option. |
| + | |
| + | ; --end <integer> |
| + | : This option specifies the end position of the region to be analyzed. Would not work without <code>--chr</code> option. |
| + | |
| + | ; --window <integer> |
| + | : This option specifies the length of buffer region in units of base pairs on either side of the region to be analyzed. Would not work without <code>--chr</code> option; otherwise, it is set as 500000 by default. |
| | | |
| == Approximation Parameters == | | == Approximation Parameters == |
| + | ;--minimac3 |
| + | : OFF by default. If ON, Minimac3 algorithm will be used for imputation. |
| + | |
| + | ;--probThreshold <float_number> |
| + | |
| + | ;--diffThreshold <float_number> |
| + | |
| + | ;--topThreshold <float_number> |
| | | |
| == Other Parameters == | | == Other Parameters == |
| + | ; --log |
| + | : OFF by default. If ON, information including warnings and errors will be saved into <output_prefix>.logfile, instead printed on the screen. |
| + | |
| + | ; --help |
| + | : If ON, it will show the list of all available options. |
| + | |
| + | ;--cpus <integer> |
| + | : This option defines the number of cpus for parallel computing, 1 by default. |
| | | |
| == PhoneHome == | | == PhoneHome == |
| + | ;--noPhoneHome |
| + | : OFF by default. If ON, code will NOT send a SUCCESS/FAILURE status of the execution to home server. |
| + | |
| + | ;--phoneHomeThinning <integer> |
| + | : Percentage probability of sending SUCCESS/FAILURE status of the execution to home server, 50 by default. |