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, 04:30, 26 October 2010
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| == Overview == | | == Overview == |
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− | This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses three possible strategies for handling population structure, specifically: | + | This lecture introduces the problem of population stratification in the context of genetic association studies. It also discusses introduces several possible strategies for detecting and handling population structure, specifically: |
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− | * Using family based association tests, such as the TDT. | + | * Q-Q plots as a diagnostic tool in genetic association studies. |
− | * Controling the overall inflation of test statistics, using the genomic control method. | + | * Using family based association tests, such as the TDT, to avoid spurious association even when a single marker is tested. |
− | * Using genotype based matching approaches. | + | * Using the genomic control method to controling the overall inflation of test statistics, when many markers are tested. |
| + | * Using genotype based matching approaches to model population structure more explicitly. |
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| == Lecture Notes == | | == Lecture Notes == |