Changes

From Genome Analysis Wiki
Jump to navigationJump to search
1,018 bytes added ,  09:40, 26 November 2010
Created page with 'This page documents how to perform X chromosome (non-pseudo-autosomal part) imputation using MaCH [http://www.sph.umich.edu/csg/yli/mach] and minimac [http://genome.sph.umich.edu…'
This page documents how to perform X chromosome (non-pseudo-autosomal part) imputation using MaCH [http://www.sph.umich.edu/csg/yli/mach] and minimac [http://genome.sph.umich.edu/wiki/Minimac].

== Getting Started ==

=== Your Own Data ===
To get started, you will need to store your data in [[Merlin]] format pedigree and data files, one per chromosome. For details, of the Merlin file format, see the [http:/www.sph.umich.edu/csg/abecasis/Merlin/tour/input_files.html Merlin tutorial].

Within each file, markers should be stored by chromosome position. Alleles should be stored in the forward strand and can be encoded as 'A', 'C', 'G' or 'T' (there is no need to use numeric identifiers for each allele).

Note that for males hemizygotes are coded as homozygotes.

=== Reference Haplotypes ===
You can download the following reference haplotypes from MaCH download page [http://www.sph.umich.edu/csg/yli/mach/download/chrX.html].

== Two-Step Imputation ==

=== Phase Your Own Data ===

=== Impute ===

== FAQ ==
212

edits

Navigation menu