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Mach DAC

414 bytes added, 15:33, 29 November 2010
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This is the MaCH Divide and Conquer page, documenting how to break the genome into smaller pieces before imputation/phasing and how to ligate after imputation/phasing.
== Phase Phasing without External Reference ==
=== Your Data ===
To get started, you will need to store your data in [[Merlin]] format pedigree and data files, one per chromosome. For details of the Merlin file format, see the Merlin tutorial [http://www.sph.umich.edu/csg/abecasis/Merlin/tour/input_files.html]. <br>
You can split your data using [http://www.sph.umich.edu/csg/yli/splitPed/ splitPed].
== PhasePhasing/Imputation with External Reference ==When you phase/impute with external reference panel, you will only need to break the reference files into parts containing subsets of markers because SNPs in your own data (pedigree files) but not in reference files will be automatically ignored by MaCH and minimac. <br> You can split the reference files using [http://www.sph.umich.edu/csg/yli/splitPed/ splitHap]. == Post Phasing/Imputation Ligation ==  
== Questions and Comments? ==
Email [mailto:yunli@med.unc.edu Yun Li].
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