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The initial set of genotype calls is generated examining a single individual at a time. These calls are typically quite good for deep sequencing data, but much less accurate for low pass sequence data. In either case, they can be greatly improved by models that combine information across sites and individuals and consider the contraints imposed by parent-offspring trios.
The initial set of genotype calls is generated examining a single individual at a time. These calls are typically quite good for deep sequencing data, but much less accurate for low pass sequence data. In either case, they can be greatly improved by models that combine information across sites and individuals and consider the contraints imposed by parent-offspring trios.
Pedigree file in [http://www.sph.umich.edu/csg/abecasis/Merlin/tour/input_files.html MERLIN format].
Here is a summary of the TrioCaller command line options (these are also listed whenever you run the program with no parameters):
Here is a summary of the TrioCaller command line options (these are also listed whenever you run the program with no parameters):
