Changes

== Preparing Input Files for rareMETALS ==

== Preparing Input Files for rareMETALS ==

## Generate summary level statistic files: Summary statistics files can be generated by rvtests [https://github.com/zhanxw/rvtests] or rare-metal-worker [http://genome.sph.umich.edu/wiki/Rare-Metal-Worker]

# Generate summary level statistic files: Summary statistics files can be generated by rvtests [https://github.com/zhanxw/rvtests] or rare-metal-worker [http://genome.sph.umich.edu/wiki/Rare-Metal-Worker]

 

# Annotate your summary level statistics: In order to perform gene-level association test, summary level statistics file have to be annotated first. The default program for performing annotations is ANNO (by Xiaowei Zhan). The usage of the program can be found at [https://github.com/zhanxw/anno]

## Annotate your summary level statistics: In order to perform gene-level association test, summary level statistics file have to be annotated first. The default program for performing annotations is ANNO (by Xiaowei Zhan). The usage of the program can be found at [https://github.com/zhanxw/anno]

# Compress and Index Summary Statistics: Files rareMETALS R-package takes compressed and tabix-indexed files as input for performing meta-analysis  

 

## Compress and Index Summary Statistics: Files rareMETALS R-package takes compressed and tabix-indexed files as input for performing meta-analysis  

    

    

== Performing single variant association analysis ==

== Performing single variant association analysis ==