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== Description and Rationale ==

== Description and Rationale ==

EMADS is a collaborative effort of many studies to investigate the potential role of rare exomic variation on drinking and smoking phenotypes. Through the effort we hope to extend results of previous GWAS meta-analyses of drinking and smoking, as well as identify novel genetic associations.

EMADS is a collaborative effort of many studies to investigate the potential role of rare exomic variation on drinking and smoking phenotypes. Through the effort we hope to extend results of previous GWAS meta-analyses of drinking and smoking, as well as identify novel genetic associations.

We use the exome chip as the primary genotyping technology, largely because larger samples have been genotyped on the exome chip (compared to sequencing). However, some studies also have whole genome or exome sequences, and these will be included in analysis whenever feasible.

 

We use the exome chip as the primary genotyping technology, largely because larger samples have been genotyped on the exome chip (compared to sequencing). However, some studies also have whole genome or exome sequences, and these will be included in analysis whenever feasible.

== Analysis Projects ==

== Analysis Projects ==