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Welcome! This is an informational page devoted to the EMADS consortium, the exome meta-analysis of drinking and smoking. This page has a description of the project and standard documents related to the effort.  

Welcome! This is an informational page devoted to the EMADS consortium, the exome meta-analysis of drinking and smoking.

== Contact  ==

== Contact  ==

== Description and Rationale  ==

== Description and Rationale  ==

EMADS is a collaborative effort of many studies to investigate the potential role of rare exomic variation on drinking and smoking phenotypes. Through the effort we hope to extend results of previous GWAS meta-analyses of drinking and smoking, as well as identify novel genetic associations.  

EMADS is a collaborative effort of many studies to investigate the potential role of rare exomic variation on drinking and smoking phenotypes. Through the effort we hope to extend results of previous GWAS meta-analyses of drinking and smoking as well as identify novel genetic associations. As of this writing over 20 studies plan to contribute a total of 120,000 samples. Several other studies hope to contribute but, given the novelty of the exome chip genotyping array, are awaiting completion of genotyping.

We use the exome chip as the primary genotyping technology, largely because larger samples have been genotyped on the exome chip (compared to sequencing). However, studies with sequences are more than welcome and can easily be included in our current analysis efforts.

We use the exome chip as the primary genotyping technology, largely because larger samples have been genotyped on the exome chip (compared to sequencing). However, studies with sequences are more than welcome and can easily be included in our current analysis efforts.

== Analysis Projects  ==

== Analysis Projects  ==

The current primary goal of the EMADS consortium is a genome-wide exomic analysis of nonsynonymous variation in smoking and drinking phenotypes. Please see the [[EMADS Primary Analysis Plan|Analysis Plan]].  

The current primary goal of the EMADS consortium is a genome-wide exomic analysis of nonsynonymous variation in smoking and drinking phenotypes.  

 

Please see the [[EMADS Primary Analysis Plan|Analysis Plan]].  

We hope to expand the list of possible projects using the data available through our consortium. These may include a project headed by Nancy Saccone and Laura Beirut on detailed analysis of the chromosome 15 region and smoking.  

We hope to expand the list of possible projects using the data available through our consortium. These may include a project headed by Nancy Saccone and Laura Beirut on detailed analysis of the chromosome 15 region and smoking.