Changes

'''Running Times'''

'''Running Times'''

Run times depend heavily on the type of analysis. If all samples are unrelated, and no kinship matrix is used, then run times should be relatively fast (tens of minutes). If a mixed model is used, for example using an empirical kinship, then in samples of a few thousand rare-metal-worker should take less than 20 minutes to complete. In larger samples (~10,000 or more with phenotype data) it can take several days to complete an exome-chip-wide scan.

Run times depend heavily on the type of analysis. If all samples are unrelated, and no kinship matrix is used, then run times should be relatively fast (tens of minutes). If a mixed model is used, for example using an empirical kinship, then in samples of a few thousand rare-metal-worker should take less than 20 minutes to complete. In larger samples, especially of related individuals (~10,000 or more with phenotype data), it can take several days to complete an exome-chip-wide scan.

'''Submitting Results for Meta-Analysis'''

'''Submitting Results for Meta-Analysis'''

All output files from Rare-Metal-Worker can then be uploaded to an sftp server at the University of Michigan for central analysis -- please email [mailto:svrieze@umich.edu Scott Vrieze] for the hostname, username, and password.

All output files from Rare-Metal-Worker can then be uploaded to an sftp server at the University of Michigan for central analysis -- please email [mailto:svrieze@umich.edu Scott Vrieze] for the hostname, username, and password. One site used Aspera to transmit results, which worked well.

=== Stage 2: Single-Variant and Gene-Based Meta-Analysis ===

=== Stage 2: Single-Variant and Gene-Based Meta-Analysis ===